Listar por autor "González-Álvaro, Isidoro"

Mostrando ítems 1-6 de 6

    • Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study 

      Ferreiro-Iglesias, Aida; Calaza, Manuel; Pérez-Pampin, Eva; López-Longo, J.; Marenco, José L.; Blanco García, Francisco J; Narváez, Javier; Navarro, Federico; Cañete, Juan D.; Rodríguez de la Serna, Arturo; González-Álvaro, Isidoro; Herrero-Beaumont, Gabriel; Pablos, José L.; Balsa, Alejandro; Fernández-Gutiérrez, Benjamín; Cáliz, Rafael; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-09-27)
      [Abstract] INTRODUCTION: Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...

    • Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations 

      Márquez, Ana; Kerick, Martin; Zhernakova, Alexandra; Gutiérrez-Achury, Javier; Chen, Wei-Min; Onegut-Gumuscu, Suna; González-Álvaro, Isidoro; Rodríguez-Rodríguez, Luis; Ríos-Fernández, Raquel; González-Gay, Miguel Á.; Mayes, Maureen D.; Raychaudhuri, Soumya; Rich, Stephen S.; Wijmenga, Cisca; Martín, Javier (BMC, 2018-12-20)
      [Abstract] Background. In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The ...

    • Profile of matrix-remodeling proteinases in osteoarthritis: impact of fibronectin 

      Pérez-García, Selene; Carrión, Mar; Gutiérrez-Cañas, Irene; Villanueva-Romero, Raúl; Castro, David; Martínez, Carmen; González-Álvaro, Isidoro; Blanco García, Francisco J; Juarranz, Yasmina; Gomariz, Rosa P. (MDPI, 2019-12-22)
      [Abstract] The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes ...

    • Spanish Rheumatology Society and Hospital Pharmacy Society Consensus on recommendations for biologics optimization in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis 

      González-Álvaro, Isidoro; Martínez-Fernández, Carmen; Dorantes-Calderón, Benito; García-Vicuña, Rosario; Hernández-Cruz, Blanca; Herrero-Ambrosio, Alicia; Ibarra-Barrueta, Olatz; Martín-Mola, Emilio; Monte-Boquet, Emilio; Morell-Baladrón, Alberto; Sanmartí, Raimon; Sanz-Sanz, Jesús; De-Toro, Javier; Vela, Paloma; Román Ivorra, José Andrés; Poveda-Andrés, José Luis; Muñoz-Fernández, Santiago (Oxford University Press, 2014-12-19)
      [Abstract] Objective. The aim of this study was to establish guidelines for the optimization of biologic therapies for health professionals involved in the management of patients with RA, AS and PsA. Methods. Recommendations ...

    • Urine metabolome profiling of immune-mediated inflammatory diseases 

      Arnald Alonso, Antonio Juliá; Vinaixa, María; Domènech, Eugeni; Fernández-Nebro, Antonio; Cañete, Juan D.; Ferrándiz, Carlos; Tornero, Jesús; Gisbert; Nos, PIlar; Gutiérrez Casbas, Ana; Puig, Lluís; González-Álvaro, Isidoro; Pinto-Tasende, José A.; Blanco, Ricardo; Rodríguez, Miguel A.; Beltrán, Antoni; Correig, Xavier; Marsal, Sara (Springer, 2016-09-08)
      [Abstract] Background, Immune-mediated inflammatory diseases (IMIDs) are a group of complex and prevalent diseases where disease diagnostic and activity monitoring is highly challenging. The determination of the metabolite ...

    • Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis 

      López-Lasanta, María; Juliá, Antonio; Maymó, Joan; Fernández-Gutiérrez, Benjamín; Ureña-Garnica, Inmaculada; Blanco García, Francisco J; Cañete, Juan D.; Alperi-López, Mercedes; Olivé, Alex; Corominas, Héctor; Tornero, Jesús; Erra, Alba; Almirall, Miriam; Palau, Nuria; Ortiz, Ana; Ávila, Gabriela; Rodríguez-Rodríguez, Luis; Alonso, Arnald; Tortosa, Raül; González-Álvaro, Isidoro; Marsal, Sara (BMC, 2015-09-04)
      [Abstract] Introduction. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. ...